Red Light Therapy Photobiomodulation

Poor circulation and the lack of oxygen and other essential molecules (i.e., glucose, Adenosine Triphosphate (ATP)) in blood vessels can cause pain or a lack of sensation. Macrophages exposed to red light therapy release cytokines (over 100 proteins produced by white blood cells that signal immune response to inflammation) that stimulate the production of growth factors influencing the inflammatory process, healing, and wound repair.

There is actually very little research on using LED therapy for hyperpigmentation but the available research points to red and near-infrared being beneficial. Here’s how it apparently works according to one study*: Near-infrared… “significantly reduced melanin production and tyrosinase expression, not only in a normal human melanocyte monoculture both with and without forskolin stimulation but also in a three-dimensional multiple cell type culture. It reduced melanin content via inactivation of the apoptosis signal-regulating kinase and extracellular signal-regulated kinase 1/2 pathways. The level of phosphorylated cyclic AMP response element-binding protein was also decreased by LED irradiation. Moreover, LED irradiation reduced melanogenesis through decreased expression of tyrosinase family genes (tyrosinase-related protein-1 and 2, and microphthalmia-associated transcription factor). These results indicate that LEDs could potentially be used to treat melanin-overproducing skin conditions.”* Light-emitting Diodes at 830 and 850 nm Inhibit Melanin Synthesis In vitroJeong Mo Kim, Nan-Hyung Kim, Yu Shun Tian and Ai-Young Lee Dongguk University Research Institute of Biotechnology Medical Science Research Center, and Department of Dermatology, Dongguk University Ilsan Hospital, Gyeonggi-do, South Korea.

Light Therapy stimulates lymph activity, helping to reduce edema, or fluid buildup. Increasing lymph activity also can help to quicken the healing process, because the lymph system is responsible for helping the body to eliminate waste products and bacteria. Macrophages are stimulated by LED light therapy. Within the lymph nodes, macrophages destroy microorganisms — this process is called phagocytosis — so that the lymph system can begin the process of removing them from the body.

The wavelengths have a direct positive influence on the fibroblasts. This stimulation will increase the demand for natural hyaluronic acid. This increase in natural HA will increase hydration as the HA attracts 20 times its body weight in water resulting in more hydration.

The Celluma RESTORE’s hair program is the only Celluma program FDA-cleared to treat and restore thinning hair in those suffering from certain categories of androgenetic alopecia. Research has shown that red light energy delivered within specific parameters can prolong the anagen (growing) phase of the hair and prevent the onset of the catagen phase (death) of the hair.

Your skin is the most miraculous “bio-barrier ever designed. It’s meant to keep things out. We have not seen any rigorous clinical studies that prove there is a synergistic effect between LED treatment and serum penetration. The molecules in topically applied products are just too big to be “driven” deeper into the tissue. We do however know that the serums being sold by other light therapy companies can block light penetration by 30 – 100%, curtailing the therapeutic benefit of the light therapy. When you consider that topical treatments are intended to affect only the first couple millimeters of the skin and light therapy penetrate as deep as 25mm below the surface of the skin, down into the subcutaneous tissue, why would you ever put something on the skin that would diminish the impact of the light therapy. For this reason, we always recommend that light treatments be done on clear, dry, bare skin and the application of products should follow.